ZMC Ceftriaxone Sodium Injection and Infusion

Ceftriaxone sodium 1g/0.5g


Ceftriaxone sodium is a third-generation, broad-spectrum and long-acting cephalosporin. It is bactericidal against both Gram-negative and Gram-positive. It is also highly stable to β-lactamase.


Clinically used for the infections due to susceptible pathogens:

• Respiratory tract infections: Pneumonia, bronchitis, pulmonary suppuration, pyothorax

• Otorhinolaryngologic infections

• Renal and urinary tract infections: pyelonephritis, prostatitis, cystitis, urethritis.

• Urogenital infections, especially for gonorrhea and soft chancre.

• Abdominal infections: Peritonitis, biliary and gastrointestinal infections

• Meningitis

• Osseous, articular, soft tissue, skin and wound infections

• Septicemia

• Prophylaxis in operation and post-operative infections


For I.M., dissolve 1g/0.5g of Ceftriaxone sodium in 4ml/2ml of 1% Lidocaine.

For I.V., dissolve -1g/0.5g of Ceftriaxone sodium in 10ml/5ml of water for injection.


• Adults: I.M. or I.V. drip. 1 – 2g once per day. Dosage can be increased to 3 – 4 per day in severe infection.

In Lyme disease: 2g per day, as one injection.

• Children and infants: 20-80mg/kg/day, as one injection.

In Lyme disease: 50-100mg/kg/day, as one injection.

In meningitis: 50-100mg/kg/day, as one injection.

* In gonorrhea: The recommended dosage is I.M. 0.25g as one injection.


• Alimentary tract: Soft faeces, diarrhea, nausea

• Skin: Rash, itching, urinary, edema, Steven-Johnson Syndrome.

• Blood: eosinophilia, leucocytopenia transient increase in serum transanmmase and serum creatinine.

• Other rare reactions: Headache, vertigo, increase in liver transaminases, uropenia, genital mycosis, fever or shivering.

• Pseudo membranous enteritis and disturbance of coagulation are more rarely seen.

• Local reaction: Occasional phlebitis at the I.V. injection point.


Any allergic reactions should be reported to the physician.

The reconstituted solution for I.M. injection containing Lidocaine must not be used in intravenous way.


Take this medicine with precautions in the following situations:

• Severely impaired kidney function or concomitant impaired kidney and liver function (need for dose adjustment).

• Neonatal hyperbilirubinemia.

• Prolonged- treatment (need for regular checks for blood Count).

• Those who are allergic to Penicillin would be cross-allergic to this medicine.
Before taking this medicine you should tell your doctor if you have.

• History of urticaria or any other skin rash, itching or anginoneurotic edema due to an antibiotic use.

• Pain in your right side of abdomen.

• Any other concomitant use of medicines or ongoing treatment.
Pregnancy women can use this medicine if the physician thinks necessary.


Breast-feeding women and those who are allergic to cephalosporins are forbidden.