Wormhooker Albendazole Tablets

WORMHOOKER TABLETS 400 mg
Albendazole Tablets

 

For the use of a Registered Medical Practitioner or Hospital or a Laboratory only.

 

Composition

Each chewable tablet contains:

Albendazole USP 400mg

Excipients q.s.

 

Description

Albendazole has advantage of single dose administration in many cases like ascariacis, hookworm (both species) and enterobasia.

Up to 75% patients are also cured of strongyloides tapeworms, H.nana is relatively insensitive. It expels Trichinella spiralis from intestines but efficacy in killing larvae that have migrated to muscle is uncertain.

Prolonged treatment has been shown to cause regression of hydatid cysts in liver, surgery may thus be avoided. It acts probably by blocking glucose uptake in parasite & depletion of its glycogen stores.

 

Clinical Pharmacology

Albendazole is a benzimidazole carbamate with anthelmintic and antiprotozoal activity against intestinal and tissue parasites. Animal studies have shown that albendazole exhibits vermicidal ovacidal and larvacidal activity and exerts its anthelmintic effect by inhibiting tubulin polymerization. This causes the disruption of the helminth metabolism, including energy depletion, which mobiIises and then kills the susceptible helminth.

 

Indications & Usage

Albendazole tablet is an oral drug designed to treat different kinds of worm infestations. The active ingredient Albendazole is an anthelmintic and works by killing sensitive parasites.

 

Usage

Albendazole is an anthelmintic exhibiting vermicidal, ovicidal and larvicidal activity, and is effective in the treatment of the following intestinal and tissue parasites: Roundworm (Ascaris lumbricoides), Whip worm (Trichuris trichuria), Pinworm/threadworm (Enterobious vermicularis). Hookworm (Ancylostoma duodenale and Necator americanus), Srongyloides stercoralis, Taenia solium, Taenia saginata, Opisthorchis viverrini, also hydatid cysts. It is thought to kill these worms by causing them to starve.

 

Contraindications

Contraindicated in pregnant and breastfeeding women, neonates, patients with known hypersensitivity, and liver impairment.

 

Drug Interaction

Antidiabetic agents potentiates their action. H2 antagonist increases the plasma concentration of Albendazole.

 

Warnings & Precautions

*Monitor blood counts and liver function.

*Administer within 7 days of start of normal menstruation in women of childbearing age.

*Adequate non-hormonal contraceptive measures must be taken during and for 1 month after therapy.

*Perform liver function tests and blood counts before and every 2 weeks during high dose therapy of hydatid disease.

*It may cause bone marrow depression.

*It may cause dizziness. Do not drive or perform other possibly unsafe tasks until you know how your react to it.

 

Pregnancy & Lactation

There are no adequate and well-controlled studies of albendazole administration in pregnant women. Albendezole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Pregnancy (Cat. C): obtain (-) pregnancy test first. Avoid pregnancy during or for at least 1 month after stopping; discontinue if pregnancy occurs.

Nursing mothers.

 

Adverse reaction

As specified below there are certain side effects aligned with Albendazole. In case you do observe any unwished effects, do consult your physician or pharmacist, because some of these side effects may need medical assistance.

Nausea, Vomiting, Dizziness, Headache, Insomnia, Infection, Stomach pain, Aggression, Temporary hair loss.

 

SYMPTOMS OF OVERDOSAGE AND ANTIDOTE

If poisoning or excessive overdosage is suspected it is recommended, on general principles, that vomiting be induced or gastric lavage be performed, and such symptomatic supportive therapy be administered as appears indicated.

 

Dosage and administration

Adults & Children above 2yrs: 400mg as a single dose.

Strongyloidiasis, Taniasis, H.nana infections: 400 mg once daily for 3 consecutive days.

Hydatid disease: 400mg twice daily with meals for 28 days. Therapy may be repeated after 14 days intervals for a total of 3 cycles or as directed by Physician.

 

Storage

Store in a cool and dry place, away from light.

KEEP OUT OF REACH OF CHILDREN.

 

Presentation

Carton of 10 mono cartons with 1 blister of 1 tablet each.

 

Manufactured in India by

Maxheal Pharmaceuticals (India) Ltd.

H.O. Maxheal House, Bangur Nagar, Goregaon (W),

Mumbai-400 090

Factory: 95/6, M.I.D.C., Satpur, Nashik-422 007

www.maxheal.in

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