Sivotheotamol Theophylline and Salbutamol Tablet

SIVOTHEOTAMOL TABLET

 

DESCRIPTION

Sivotheotamol contains an active ingredient Theophylline and salbutamol. Theophylline chemical name is 1,3-Dimethyl-3,7- dihydro-1H-purine-2,6-dione. Salbutamol chemical name is (1RS)-2-[(1,1-Dimethylethyl)amino]-1-(4-hydroxy- 3(hydroxymethyl)phenyl]ethanol.

 

LABEL CLAIM

Each uncoated tablet contains:
Theophylline (Anhydrous) BP 100mg
Salbutamol Sulphate BP
equivalent to salbutamol 2mg
Colour: Erythrosine

 

MECHANISM OF ACTION

PHARMACODYNAMICS

Salbutamol is a seIective β2- agonist. It causes bronchial smooth muscle relaxation via the cyclic adenyl cyclase (CAMP) system. Theophylline is a phosphodiesterase inhibitor. It enhances intracellular cAMP conc thereby contributing to bronchial smooth muscle relaxation.

 

PHARMACOKINETICS

Theophylline is well absorbed from uniphyllin continus tablets and at least 60% may be bound to plasma proteins. The main urinary metabolites are 1,3-dimethyl uric acid and 3-methylxanthine. Salbutanol is readily absorbed from the gastrointestinal tract. Its effects occur within 15 minutes and last for about 14 hours.

 

INDICATIONS

For the relief of bronchospasm in bronchial asthmas of all types. Chronic bronchitis, Emphysema, inhibition of premature labour in selected patients where a definite benefit is likely to occur.

 

DOSAGE

Oral, 1 or 2 tab 3-4 times daily.

 

CONTRAINDICATION

Hypersensitivity, thyrotoxicosis.

 

DRUG INTERACTION

Increased theophylline toxicity with propranolol, cimetidine, erythromycin (7-5 days), quinolone antibiotics.

 

SIDE EFFECTS

Seizures, tremor, muscle cramps, palpitation, hypokalaemia, headache; anorexia, nausea, anxiety, irritability, insomnia, rarely rash and angioedema.

 

OVER DOSAGE

If overdose is suspected, contact the hospital nearest to you immediately. Symptoms of overdose may include: seizures, increase in blood pressure, increase in heart rate, nervousness, headache, dry mouth, palpitation, nausea, dizziness and sleep deprivation.

 

KEEP OUT OF THE REACH OF CHILDREN.

 

PACKING

10 x 10 Tablets packed in Strip along with pack insert.

 

NAFDAC Regn. No. : A4-8866

 

Manufactured in India by

Rhydburg Pharmdceuticals Ltd.

C-2 & 3, S.I.E.L., Selaqui, Dehradun

Uttarakhand, INDIA

 

Manufactured for

Adpharm Pharmaceuticals Ltd.

60 Ajao Road, Surulere,

Lagos State, Nigeria

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