Predicure Prednisolone Tablet

PREDICURE®
Prednisolone Tablet B.P.5mg

 

DRUG NAME

Prednisolone Tablets, chemical name: 11β, 17, 21- trihydroxypregna-1, 4-diene – 3, 20-dione. Structural formula C21H28O5 360.4

 

DESCRIPTION

Round, white film-coated tablets, shallow convex faces. “Pred” embossed and scored on the same face.

 

COMPOSITION

Each tablet contains: Pednisolone 5mg

 

PHARMACOLOGICAL & TOXICOLOGICAL

Prednisolone, a synthetic glucocorticoid, has both anti-inflammatory and immunosuppressant actions. It acts by inhibition of phagocytosis, leukocyte migration and capillary dilatation, and prevention or suppression of cell-mediated (delayed hypersensitivity) immune reactions respectively. It is readily absorbed orally, metabolized in the liver and excreted via the kidneys.

 

PHARMACOKINETICS

This product activity in the form of easily absorbed from the digestive tract, without transformation of the liver that exert their biological effects. About 1-2 hours after oral administration, plasma concentration reaches the peak T1/2 is 2-3 hours. In the blood most of the food with the plasma protein binding free and conjugated metabolites from the urine discharged from a portion of the prototype, a small number of milk may be discharged.

 

INDICATIONS

Prednisolone is used is the treatment of conditions where a routine systemic corticosteroid therapy is indicated. Its weaker sodium retaining action usually makes it more suitable than cortisone in such conditions as rheumatoid arthritis, rheumatic fever, status asthmaticus and ulcerative colotis.

 

DOSAGE & ADMINISTRATION

Adults: Oral, 5 to 60mg a day as a single dose or in divided doses, not exceeding 250mg daily. Or as directed by physician.

Children: As directed by physician.

Note: The paediatric dosage is determined more by the severity of the condition and response of the patient than by age or body weight.

The information given here is limited. For further information consult your doctor or pharmacist.

 

CONTRAINDICATIONS

Use is not recommended in nursing mother, wherever possible.

 

SIDE EFFECTS

Dyspepsia, peptic ulceration, long-term use include Cushing’s syndrome, acne, osteoporosis, mental changes and endocrine imbalance.

 

PRECAUTION

1, Caution in patients with osteoporpsis ulcer, psychoses fungal infections, diabetes mellitus, hypertension, myasthenia gravis, ocular herpes simplex, glaucoma,
hypothyroidism, history of tuberculosis, renal and hepatic function impairment.

2, When medication is to be discontinued, dosage should be reduced gradually. Abrupt cessation of prolonged therapy may produce acute adrenal insufficiency.

3, Frequent monitoring of drug effect is required.

4, Caution in receiving vaccinations, other immunizations and skin test

5, Children on prolonged therapy should be closely observed.

6, Safety for use in pregnancy has not been established.

7, Overdosage: Clinical features: Nausea and vomiting, hyperglycaemia, occasional gastrointestinal bleeding. Treat overdose by symptomatic measures.

 

DRUG INTERACTIONS

1, Response to prednisolone maybe reduced by co-administration of barbiturates, phenytoin or rifampicin.

2, Effects of oral anticoagulants or salicylates may be decreased when used concurrently with prednisolone.

3 Caution in patients receiving the following drug therapy: Alcohol, anti-inflammatory medications, cardiac glycosides, ephedrine, heparin, hypoglycaemics.

 

PRESENTATION

5mg/Tablet, 10 tablets/blister, 10 blisters/box.

 

STORAGE

Store in a well-closed container. Protected from heat and light.

KEEP ALL MEDICINES OUT OF THE REACH OF CHILDREN.

 

EXPIRY DATE

3 years.

 

Manufactured by

Unicure Pharmaceutical Ltd.

lkofa Village, Lagos – Benin Expressway, Ijebu-ode,

Ogun State, Nigeria.

Leave a Reply