Philocaine Procaine Penicillin Injection

PHILOCAINE®
FORTIFIED PROCAINE PENICILLIN FOR INJECTION I.M. B.P.

 

This preparation is available in the form of a sterile dry powder containing benzylpenicillin potassium (or sodium) and procaine penicillin with suitable amount of suspending and buffering agents. The advantage of such a preparation is that it can exert both the prompt action due to the high initial blood levels produced by the soluble potassium salt, and the prolonged action of the insoluble procaine penicillin salt which is adsorbed and excreted slowly. Therefore, a single dose injection of this preparation can maintain an effective concentration in blood for 12-24 hours.

 

Action and uses

It has the same indications as penicillin. As its peak blood concentration is relatively low, it is only indicated in mild infections caused by penicillin-sensitive bacteria such as tonsillitis, scarlet fever, crysipelas, furuncles and carbuncles. lt is also effective for syphilis, Vincent’s angina and gonorrhea.

 

Administration and dosage

It is given by i.m. injection only. A suitable amount of water for injection is added into the vial before use. 400,000 i.u. – 800,000 i.u. each time, once or twice a day.

 

Caution

1. Before administration skin tests of procaine and penicillin should be made. It should not be administrated to patients hypersensitive to penicillin and procaine.

2.The suspension prepared by adding a suitable amount of water for injection into the vial should be stored below 10°C and used up within 24 hours.

 

Presentation

1. In vials of 400,000 i.u. – each containing 300,000 i.u. of procaine penicillin and 100,000 i.u. of penicillin potassium (or sodium).

2. In vials of 800,000 i.u. – each containing 600,000 i.u. of procaine penicillin and 200,000 i.u. of penicillin potassium (or sodium).

3. In vials of 1,000,000 i.u. – each containing 750,000 i.u. of procaine penicillin and 250,000 i.u. of penicillin potassium (or sodium).

4. In vials of 1,200,000 i.u. – each containing 900,000 i.u. of procaine penicillin and 300,000 i.u. of penicillin potassium (or sodium).

5. In vials of 2,000,000 i.u. – each containing 1,500,000 i.u. of procaine penicillin and 500,000 i.u. of penicillin potassium (or sodium).

6. In vials of 3,000,000 i.u. – each containing 2,250,000 i.u. of procaine penicillin and 750,000 i.u. of penicillin potassium (or sodium).

7. In vials of 4,000,000 i.u. – each containing 3,000,000 i.u. of procaine penicillin and 1,000,000 i.u. of penicillin potassium (or sodium).

 

Storage

Kept in well-closed containers and stored in a dry place.

 

Expire

Three years.
NAFDAC REG. No: A4-2118

 

Manufactured by

CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.

No. 47, Fengshou Road, Shijiazhuang City, China

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