Petsow Amoxycillin Capsules

AMOXYCILLIN CAPSULES

 

PRESENTATION

Maroon/yellow coloured hard gelatin size 1 capsule having petsow and amoxi 250 printed on the capsule shell.

 

PHARMACOLOGY

Amoxycillin is stable in acid and it is rapidly and almost completely absorbed from G.l.T after oral administration.

Food in G.I.T does not interfere with its absorption; peak serum Amoxycillin conc. Of about 5µg/ml are produced two hours after the ingestion of 250mg of Amoxycillin. About 20% of Amoxycillln is protein bound and the rest is available as free drug in the serum; Amoxycillln is mainly excreted in urine in an active form, about 60% of the dose being excreted in 6 hours, after its oral administration. Amoxycillin is bactericidal. It is highly effective against gram positive organisms including streptococci, pneumococci and penicillin sensitive staphylococci it is also active against gram negative organisms such as; Haemophilus, influenzae, Eschericie coli, Neisseria gonorrhea, Neisseria meningitis, proteus mirabilis, shigella sonnei, and salmonella species.

 

INDICATIONS

Acute and chronic bronchitis, pneumonia, bronchopneumonia, lung abscess, tonsillitis, sinusitis, laryngitis, otitis media, pharyngitis, urethritis, cystitis, nephritis, typhoid fever, bacillary dysentery: boils, carbuncle infected wound, impetigo, gonococcal infections, pre and post-operative control of infections; endocarditis, and osteomyelitis.

 

DOSAGE

The usual oral dose is amoxycillin 250mg to 500mg every 8 hours.

Children up to 10 years of age may be given 125 to 250mg every 8 hours; under 20kg body weight, a dose of 20 to 40mg per kg daily has been suggested. For the treatment of Gonorrhea, 6 dose of 3gm is recommended.

 

SIDE EFFECTS

Skin rashes are among the most common side-effects and are generally either urticarial or maculopapular.

Gastro-intestinal adverse effects such as diarrhoea, nausea and vomiting usually occur following the administration by mouth. Pseudomembranous colitis has also been reported.

 

CONTRA-INDICATIONS

Amoxycillin is contra-indicated in patients with a history of allergic reaction to Penicillins. Amoxycillin should be discontinued if skin rashes occur. It should preferably not be given to patients with infections mononucleosis since they are especially susceptible to amoxycillin induced skin rashes. Patients with lymphatic leukaemia or HIV infection may also be at increased risk of developing skin rashes.

 

PRECAUTIONS

As with any potent drug, haemopoietic, hepatic and renal function must be assessed periodically whenever treatment is given over a prolonged period. It should be used with caution in patients with known histories of allergy.

 

USAGE IN PREGNANCY

Safety during pregnancy not established.

 

STORAGE

Store in a cool, dry place at a temperature below 30°C.

 

MANUFACTURED BY

PETSOW LABORATORIES LTD

PLOT 101, EZIAMA INDUSTRIAL ESTATE

EZIAMA ABA ABIA STATE.

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