MF 20 Piroxicam Capsules

MF – 20

Piroxicam Capsules 20mg

 

Composition

Each capsule contains:

Piroxicam USP 20mg

Excipients qs

Capsule shell contains approved colours

 

Properties

MF-20 is an effective anti-inflammatory, analgesic and antipyretic drug.

MF-20 is completely absorbed after oral administration. It undergoes enterohepatic cycling and is extensively bound to plasma proteins.

 

Onset of action

Analgesic action 1 hour, antirheumatic action 7-12 days

 

Duration of action

48-72 hours.

 

Adverse effects

Nausea, heart burn, vomiting, epigastric distress, tinnitus, skin rash, oedema.

 

Contraindications

History of recurrent ulcer, NSAID induced allergy, hypersensitivity, bronchial asthma.

 

Specific precaution

Severe impairment of hepatic or renal function. Hypertension, surgery haemorrhagic disorders on prolonged used. Contraindicated in pregnancy. Use with caution in children.

 

Interactions

Antocoagulants: May prolong prothrombin time in coagulation.

B-Blockers: Antihypertensive effect may be increased.

Cyclosporine: Nephrotoxicity of both agents may be increased.

Lithium: Serum Lithium levels increased resulting in increased pharmacologic and toxic effects.

Methotrexate: Risk of methotrexate toxicity (stomatitis, bone marrow suppression nephrotoxicity) increased.

Probenecid: May increase the concentration and toxicity of MF-20

Aspirin: Displaces MF-20 from serum binding sites resulting in increased incidence of gastric irritations effects.

 

Indications

Rheumatoid arthritis, Oesteoarthritis, ankylosing spondylitis, Acute musculoskeletal disorders. Acute gout, post-operative and post-traumatic pain. Primary dysmenorrheal.

 

Dosage

Adults: 1 Capsule daily as a single dose.

Musculo-skeletal disorders: Initially 2 capsules daily for 2 days then 1 capsule daily for 7 to 14 days.

Gout: Initially 2 capsules as a single dose then 2 capsules daily in single or divided doses for next 4-6 days.

Post-operative and post-traumatic pain: 2 capsules daily in single or divided doses for first two days or as directed by the Physician.

Children: Not recommended.

 

Storage

Store in a cool, dry place.

Protect from light.

Keep all medicines away from children.

 

Presentation

Blister of 10 capsules

Carton of 1 x 10 capsules

Carton of 10 x 10 capsules.

 

NAFDAC Reg. No.: 04-1889

 

Manufactured by

Ningbo Dahongying Pharmaceutical Co., Ltd.

No. 396 Mingzhu Road, Hi-tech Park, Nongbo, China.

 

Sole Agent

Embassy Pharmaceutical and Chemicals Ltd.

Lagos-Nigeria.

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