Metrotab Metronidazole Tablets and Syrup

Metrotab TABLETS AND SYRUP

 

COMPOSITION

The active ingredient in Metrotab and Metropaed is Metronidazole 2 (2 – methyl -5-nitroimidazol – 1 -yl)ethanol.

 

PRESENTATIONS

Tablets: Metrotab 200 comes as a white, round, biconvex uncoated and scored tablet embossed MTZ 200 on one side and SKG on the other and contains 200mg Metronidazole B.P. Metrotab 400 comes as a yellow coloured round, biconvex, uncoated and scored tablet embossed MTZ 400 on one side and SKG on the other and contains 400mg Metronidazole B.P.

Suspension: Metropaed comes as a yellow coloured, flavoured suspension. Each 5ml of the suspension contains 200mg Metronidazole B.P.

 

PROPERTIES

Metrotab and metropaed have activity against several protozoa including Balantidium coli, Blastocystis hominis, Entamoeba histolytica and Giardia intestinalis. It is bactericidal to most obilgate and facultative anaerobes like Bacteroides, CIostridium spp., Gardnerella vaginalis and Heliabacter pylori.

 

INDICATIONS

Metrotab and metropaed are indicated for the treatment of amoebiasis at all sites of infection with Entamoeba histolytica, Glardiasis, Bacterial vaginosis, Trichomoniasis, Pelvic inflammatory disease. Prevention and treatment of post operative anaerobic infections and Acute necrotising ulcerative gingivitis. Metrotab and Metropaed are also indicated for the eradication of Helicobater pylori in Peptic ulcer disease, legs ulcers and Pressure sores infected with anaerobic bacteria, Balantidiasis and Blastocystis hominis infections, acute dental infections and anaerobic bacterial infections.

 

MODE OF ACTION

Both metrotab and Metropaed exert their activity through interference with DNA by a metabolite in which the nitro group of metronidazole has been reduced.

 

DOSAGE AND ADMINISTRATION

Metrotab and Metropaed should be taken at least 1 hour before food.

 

RECOMMENDED DOSAGE

DURATION OF DOSES (DAYS) ADULTS AND
CHILDREN
10 YEARS OLD
7-10 YEARS 3-7 YEARS 1-3 YEARS
TABLETS SUSPENSION
AMOEBIASIS
1. Acute invasive intestinal disease in susceptible patients
5 800mg Three times daily 10ml three times daily 5ml four times daily 5ml three times daily
2. Intestinal disease in less susceptible patients with Chronic amoebic hepatitis 5-10 400mg Three
times daily
5ml three times daily 2.5ml four times daily 2.5ml three times daily
3. Other forms of
Amoebiasis including Amoebic liver abscess
5 400mg Three times daily 5ml three times daily 2.5ml four times daily 2.5ml three times daily
4. Sysmptomless cyst Passers 5-10 400mg -800mg three times daily 5ml-10ml three times daily 5m1-10ml
three times daily
2.5ml-5ml three times daily
5. UROGENITAL
TRICHOMONIASIS
In cases of likely reinfection, a second course of treatment should be done concurrently
2 800mg in the morning and 1.2g In the evening 5ml-10ml three times daily 5ml-10ml
three times daily
2.5ml-5ml
three times daily
6. GIARDIASIS
If necessary, repeat Treatment after 2 weeks
3 2g once daily 25ml once
daily
15ml once daily 10ml once daily
7. ACUTE ULCERATIVE GINGIVITIS 3 200mg three times daily 2.5ml three times daily 2.5ml twice daily 1.2ml
three times daily

 

SIDE EFFECTS

At the recommended dosage, side effect are uncommon. The commonly reported effects include headache, weakness drowsiness, gastrointestinal disturbance like nausea, vomiting and diarrhoea, an unpleasant metallic taste, furry tongue, glossitis, stomatitis, skin rashes, pruritus urticana, darkening of the urine, insomnia and changes in mood or mental state such as depression and or confusion. Transient epileptiform seizures and peripheral neuropathy have also been reported but these are associated with prolonged treatment or high doses of metronidazole.

 

PRECAUTIONS AND WARNINGS

In patients with severe hepatic impairment, doses should be reduced. Clinical and laboratory monitoring is advised in patients receiving Metronidazole for more than 10 days, since prolonged treatment have sometimes been associated with leucopoenia and transient epileptiform seizures.

The use of Metronidazole should be avoided in pregnancy. Alcoholic beverages should not be taken while on Metronidazole therapy.

 

CONTRAINDICATIONS

Metrotab and metropaed are contra-indicated in cases of known hypersensitivity to metronidazole.

 

STORAGE

Adult Tablets: store below 35°C and protect from light.

Paediatric Suspension: store below 25°C and protect from light.

 

Shake the bottle well before use.

 

KEEP ALL MEDICINES OUT OF THE REACH OF CHILDREN

 

Manufactured in Nigeria by

SKG – Pharma Limited

7/9 Sapara Street,

Ikeja, Lagos.

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