Lokmal QS Combi Artemether Lumefantrine Paracetamol Caplets and Tablets

LOKMAL® QS-COMBI

(Artemether 80mg/Lumefantrine 480mg+Paracetamol 500mg)

 

COMPOSITION

Each Satchet of Lokmal QS contains

Artemther 80mg

Lumefantrine 480mg

Each Tablet of Emzor Paracetamol contains

Pracetamol 500mg

 

PHARMACOLOGICAL ACTION

Artemether is a semisythentic chiral acetal derivative of artemisinin. It interferes with parasite transport prateins, produces disruption of mitochondrial function, inhibits angiogenesis, and modulates host immune function. Artemether and its active metabolite have been estimated to reduce parasite biomass by approximately 10,000-fold per reproductive cycle (every 2 days). Lumefantrine is a racemic mixture of a synthetic fluorine derivative and is structurally related to quinine, mefloquine, and halofantrine. It interferes with the conversion of heme, the toxic intermediate step produced during hemoglobin break-down, to non-toxic hemozoin. Accumulation of heme and free radicals results in parasite death.

Artemether, like other artemisinin-derived compounds, acts quickly to rapidly reduce the parasite burden, while lumefantrine serves as a longer-acting agent to eliminate remaining parasites. The combination is effective in strains known to be resistant to traditional antimalarials such as chloroquine, and can be used for infections acquired in areas known to have parasites that are multidrug-resistant.

The mechanism of action of paracetamol is believed to be inhibition of cyclooxygenase (COX), with a predominant effect on COX-2. Inhibition of COX enzymes prevents the metabolism of arachidonic acid to prostaglandin H2 an unstable intermediate byproduct which is converted to pro-inflammatory compounds. In the central nervous system, inhibition of COX enzymes reduces concentrations of prostaglandin E2, which lowers the hypothalamic set-point to reduce fever, and activation of descending inhibitory serotonergic pathways to produce analgesia.

 

INDICATIONS

• Lokmal QS is indicated for the treatment of malaria in children and adults caused by all forms of plasmodium including severe malaria caused by multiple drug resistant strains of P.falciparum.

• Paracetamol is indicated for the relief of pain, headache and feverish conditions.

 

PHARMACEUTICAL PRECAUTIONS AND CONTRAINDICATIONS

LOKMAL QS is contraindicated in individuals who are hypersensitive to artemether and lumenfatrine and in the first trimester of pregnancy, except otherwise prescribed by a physician.

Due to long elimination half life of lumefantrine it is recommended that breastfeeding should not start until at least one week after stopping artemether /lumefantrine combination treatment.

 

DRUG INTERACTIONS

Specific negative drug-drug interaction was not seen. Artemether potentiates the antimalarial activity of other antimalarials. Grapefruit is known to reduce the absorption and metabolism of Artemether / Lumefantrine.

 

DOSAGE AND ADMINISTRATION

BODY WEIGHT (AGE) LOKMAL QS CAPLETS
Adult and Children  35 kg 14 Years and above) DAY 1 DAY 2 DAY 3
0 Hr 8Hrs Morning Night Morning Night
1 Caplet 1 Caplet 1 Caplet 1 Caplet 1 Caplet 1 Caplet
BODY WEIGHT (AGE) EMZOR PARACETAMOL TABLETS
Adult and Children  35 kg 14 Years and above) DAY 1 DAY 2 DAY 3
0 Hr 8Hrs Morning Night Morning Night
2 Tablets 2 Tablets 2 Tablets 2 Tablets 2 Tablets 2 Tablets

 

STORAGE CONDITION

LOKMAL QS Combi should be stored below 30°C.

 

KEEP ALL MEDICINES OUT OF THE REACH OF CHILDREN

 

PRESENTATION

LOKMAL QS CAPLETS: Blister Satchet of Six Caplets.

EMZOR PARACETAMOL TABLET: Blister Satchet of 12 Tablets.

 

Manufactured by

EMZOR PHARMACEUTICAL INDUSTRIES LIMITED

Plot 3C, BLOCK A Aswani Market Road, Isolo-Lagos Nigeria.

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