Eurofen 400 Ibuprofen Tablets

EUROFEN-400

Ibuprofen Tablets BP 400mg

 

Composition

Each sugar coated tablet contains:

Ibuprofen BP 400mg

Excipients q.s.

Aproved colour used

 

Pharmacological Action

Ibuprofen acts by inhibiting the activity of enzyme cyclo-oxygenase, resulting in decreased formation of precursors of prostaglandins and thromboxanes from arachidonic acid.

 

Indications

Ibuprofen is Indicated for the treatment of rheumatic diseases such as:

• Rheumatoid arthritis

• Osteoarthritis

• Ankylosing spondylitis

• Juvenile rheumatoid arthritis

For the relief of mild to moderate pain especially when anti-inflammatory actions may also be desired e.g., following dental or obstetric surgery, and for relief of musculoskeletal pain due to soft tissue athletic injuries (strains or sprains). For the relief of pain and inflammation of acute gouty arthritis. In the treatment of painful non-rheumatic inflammatory conditions such as athletic injuries, bursitis, capsulitis, synovitis, tendinitis or tenosynovitis. For reduction of fever. For the relief of pain associated with primary dysmenorrhoea.

 

Contraindication

Except under special circumstances this medication should not be used when the following medical problems exist:

• History of severe allergic reaction such as anaphylaxis or angioedema, induced by aspirin or other NSAIDs. Because of the possibility of cross-sensitivity due to structural relationship which exists among non-steroidal anti-inflammatory medicines, acute allergic reactions are likely to occur in patients who have exhibited allergic reactions to these compounds.

• Aspirin-induced nasal polyps associated with bronchospasm (high risk of severe allergic reactions because of cross sensitivity).

• Children under the age and 2 years.

• Active peptic ulceration.

• Safety in pregnancy and lactation has not been established.

 

Side Effects

Cardiovascular system

Tachycardia, flushing, increase in blood pressured.

Central nervous system

Confusion, hallucinations, mental depression, peripheral neuropathy, tinnitus, drowsiness; insomnia.

Gastro-intestinal system

Epigastric pain or discomfort, gastritis, haematemesis, gastro-intestinal perforation, gastro-intestinal ulceration.

Dermatological

Allergic dermatitis, erythema multiforme, Stevens- Johnson Syndrome, toxic epidermal necrolysis.

Renal

Haematuria, cystitis, renal impairment or failure, polyuria, fluid retention/oedema, acute renal failure, interstitial nephritis, nephrotic syndrome.

HaematologIcal

granulocytosis, anaemia, aplastic anaemia, eosinophilia, haemolytic anaemia, leukopeania, thrombocytopaenia.

Hypersensitivity reactions

Angiitis, angioedema, bronchospastic allergic reactions, allergic rhinitis, serum sickness like reaction, systemic lupus erythematosus, aseptic meningitis.

Ophthalmic

Amblyopia, blurred or double vision, conjunctivitis, dry irritated or swollen eyes, scotomata.

Oral

Aphthous stomatitis, gingival ulcerations.

Ear, Nose and Throat

Decreased hearing or any change in hearing, epistaxis.

Hepatic effects

Hepatitis.

Pancreatic effects

Pancreatitis.

 

Dosage and Direction for Use

Usual adult dose

Adults: The recommended dosage is 1200 mg daily in divided doses. In severe cases the initial dose in the acute phase may be increased, until the acute phase has been brought under control.

Maximum daily dose: 2.4 g per day.

Acute gout: 2400mg daily either as 800 mg, 8 hourly or 600 mg, 6 hourly until acute symptoms have been relieved. If acute symptoms do not resolve within 3 days, consult a doctor.

Juvenile Rheumatoid Arthritis: Total daily dose is 20 mg/kg of body weight in divided doses.

Pyrexia and pain: 20 mg/kg/day in divided doses.

 

Presentation

10 Tablets in one blister, 1 blisters pack in one carton.

 

Storage

Store in a cool, dry place. Protect from heat.

Keep all medicines out of reach of children.

 

Manufactured by

Medico Remedies Pvt. Ltd.

8 & 9, Dewan & Sons, Udyog Nagar,

Paighar, Maharashtra – 401 404. India.

 

Marketed by

LOKEL PHARMACEUTICAL CO. LTD.

1A, Aina George Street,

Ilupeju, Lagos, Nigeria.

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