(Vitamins B1+B6+B12+Diclofenac Sodium)
Each film-coated tablet contains:
Vitamin B1 50mg
Vitamin B6 100mg
Vitamin B12 100µg
Diclofenac Sodium 50mg
The action of Dolo-Meta B® can be attributed to its components. Diclofenac sodium is a non-steroidal anti inflammatory agent that possesses analgesic and anti-pyretic activities. It’s mode of action, like that of other nonsteroidal anti inflammatory agent is not known.
However, its therapeutic action is not due to pituitary-adrenal stimulation, but may be from the inhibitory action in the synthesis of pristaglandin. It exhibits very marked anti-rheumatic, anti-inflammatory, analgesic and anti-pyretic properties and is thus suitable for use in inflammatory and degenerative rheumatic disease as well as for the treatment of post-traumatic inflammation and swelling. In patients treated for rheumatoid arthritis and osteoarthritis, the anti-inflammatory action has been shown by reduction in joint swelling, reduction in pain, also reduction in duration of morning stiffness.
Thymine (Vit B1)Vit B12,Pyddoxine (Vit B6) is used in treating neurological symptoms such as peripheral neuritis. Vitamin B1 (Thiamine) is a water soluble vitamin. It is an essential enzyme for carbohydrate metabolism.
Severe Thymine deficiency is characterized by lactic acidosis and neurological deterioration such as peripheral neumpathy, muscle wasting and muscle weakness.
Vitamin B6 (Pyridoxine) is also a water soluble vitamin which is involved principally in amino-acid metabolism, but is also involved in carbohydrate and fat metabolism.
Its deficiency may lead to sideroblastic aneamia, dermatitis, cheilosis and neurological symptoms such as peripheral neuritis and convulsions.
Vitamin B12 (Cyanocobalamin) is a water soluble vitamin, occurs in the body mainly as methylcobalamin (mecobalamin) and as adenosylcobafamin (cobamamide).
These act as co-enzyme in nucleic acid synthesis. Deficiency is more likely in patients with malabsorption syndromes or, metabolic disorders.
Its deficiency leads to the development of megaloblastic anaemia and demyelination and other neurological damage. These vitamins when use individually or in combination has a remarkable effect on the regeneration of nerves.
Musculoskeletal and joint disorder, inflammation, pain, neuralgia and neuritis (Neuropathies).
Dolo-Meta B® is contra-indicated in patients with hypersensitivity to any of its components.
Avoid use in the presence of peptic ulcer, pregnancy, lactation hypersensitivity (e.g. asthma attacks) to acetylsalicylic acid or other NSAID agent, severe disorders of liver function in haemopoietic disorders.
Because of Diclofenac Sodium as an active ingredient, avoid concomitant administration with other NSAID. Anticoagulants, probenecid, diuretic, Beta-blocker, Codicosleroids, Oral anti-diabetics, cyclosporine, digoxin.
Should be use with caution in patients with evidence of peptic ulcer, those with unexplained gastrointestinal disorders, those with liver of kidney damage and those with high blood pressure, elderly.
Gastrointestinal upsets upper abdominal pain, nausea, diarrhea, light headedness of headaches at the start of treatment. These effects are generally mild and usually regress after a few days. Hypersensitivity reaction such as skin rash and pruritus, asthma attacks and a tendency to oedema may arise.
DOSAGE AND ADMINISTRATION
One tablet daily or as directed by physician.
Available in a box of 10 or 100 tablets.
Store below 30°C. Avoid exposure to sunlight, heat & moisture.
KEEP MEDICINES OUT OF REACH OF CHILDREN
Jiangsu Ruinian Qianjin Pharmaceutical Co., Ltd.
Chuanbu, Yixing Economic Development Zone, Jiangsu Province, China.