CARDOVASC RETARD TABLETS 20 mg
(Nifedipine Retard Tablets)
Each film coated retard-release tablet contains:
Nifedipine BP 20mg
Nifedipine, a calcium antagonist, improves oxygen supply to the myocardium with simultaneous decrease of oxygen requirements. Nifedipine has a vasodilatory effect on the peripheral arterial beds causing a fall in peripheral vascular resistance and an increase in peripheral blood flow. Ca2– channel blockers are useful in low-renin hypertension. Nifedipine dilates submaximally both clear and atherosclerotic coronary arteries, thus protecting the heart against coronary artery spasm and improving perfusion to the ischaemic myocardium. CARDOVASC RETARD -20 display controlled release characteristics.
INDICATIONS AND USAGE
Treatment and prophylaxis of chronic stable angina pectoris. Treatment of mild to moderate hypertension.
PRECAUTIONS AND CONTRAINDICATIONS
Although a “steal” effect has not been demonstrated, patients experiencing this effect should discontinue nifedipine therapy. Special Precautions: Care should be exercised in dialysis patients with malignant hypertension and irreversible kidney failure with hypovolaemia as a marked fall in blood pressure may occur. Sensitivity to nifedipine, Pregnancy and lactation. CARDOVASC RETARD – 20 must not be used in patients with cardiovascular shock. CARDOVASC RETARD should be used with caution in patients with a poor cardiac reserve. In patients with impaired liver function, careful monitoring of the dosage is recommended and in severe cases, a dose reduction may be necessary. There are no recommendations for use in children. Reactions to the drug, which vary in intensity from individual to individual, can impair the ability to drive or to operate machinery. This applies particularly at the start of the treatment, on changing the medication and in combination with alcohol.
Care must be exercised in patients with very low blood pressure (severe hypotension with systolic pressure less than 90 mmHg) in cases of manifest heart failure and in the cases of severe aortic stenosis. Care must be exercised in pregnant women, when administering nifedipine in combination with i.v. magnesium stearate. In patients with impaired liver function careful monitoring and, in severe cases, a dose reduction may be necessary.
Headache, facial flushing, dizziness, and nausea, a feeling of warmth, tiredness and gastrointestinal disturbances may occur. Syncope has been reported, but a recurrence can be prevented by a reduction in the dose of CARDOVASC RETARD 20. Tachycardia, peripheral oedema (unrelated to congestive cardiac failure), perspiration and nervousness have been reported. An increased frequency of Angina may occur. Myocardial infarction, reversible gynaecomastica and gingival hyperplasia have been reported. There have been reports of abnormalities in liver function due to hypersensitivity reactions.
DOSAGE AND ADMINISTRATION
The usual dose is 20mg to 40mg twice per day.
Store in a cool, dark and dry place.
5 strips of 10 tablets are packed in a printed carton.
Manufactured in India by
515, M.I.E., Bahadurgarh, Hryana.
May & Baker Nigeria PLC
3/5, Sapara Street, Industrial Estate.